silica gel reagents silica gel 60, 230-400 mesh astm (Merck & Co)
90
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Merck & Co
silica gel reagents silica gel 60, 230-400 mesh astm
Silica Gel Reagents Silica Gel 60, 230 400 Mesh Astm, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/reagents+silica+gel+60/f254/pm11667176-211-5-7
Average 90 stars, based on 1 article reviews
Silica Gel Reagents Silica Gel 60, 230 400 Mesh Astm, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/reagents+silica+gel+60/f254/pm11667176-211-5-7
Average 90 stars, based on 1 article reviews
silica gel reagents silica gel 60, 230-400 mesh astm - by Bioz Stars,
2026-10
90/100 stars
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Thin Layer Chromatography:Article Title: Hepatocellular carcinoma targeting agents: conjugates of nitroimidazoles with trimethyl nordihydroguaiaretic acid. Article Snippet: Hepatocellular carcinoma (HCC) is a major global health problem, with >626 000 new cases per year worldwide.. In North America, Asia, and Europe, it is the third highest cause of cancer-related death, behind lung and colon cancers.. 3] A rise in the incidence and mortality of HCC has been observed in most industrialized nations over the past three decades. Article Title: Multi-arm linker for treating rejection reaction in transplantation Article Snippet: .. Analytical thin-layer chromatography (TLC) was performed on precoated plates (silica gel 60 F-254), purchased from Merck Inc. Purification by column chromatography was conducted using Merck Article Title: Discovery of 4-Aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 Inhibitors. Part I: Optimization of in Vitro Potencies and Pharmacokinetic Properties Article Snippet: A series of 4-aryl-N-arylcarbonyl-2-aminothiazoles of scaffold 4 was designed and synthesized as Hec1/ Nek2 inhibitors.. Structural optimization of 4 led to compound 32 bearing C-4′ 4-methoxyphenoxy and 4-(o-fluoropyridyl)carbonyl groups that showed low nanomolar in vitro antiproliferative activity (IC50: 16.3−42.7 nM), high intravenous AUC (64.9 μM·h, 2.0 mg/kg) in SD rats, and significant in vivo antitumor activity (T/C = 32%, 20 mg/kg, IV) in mice bearing human MDA-MB-231 xenografts.. Cell responses resulting from Hec1/Nek2 inhibition were observed in cells treated with 32, including a reduced level of Hec1 coimmunoprecipitated with Nek2, degradation of Nek2, mitotic abnormalities, and apoptosis. Article Title: Discovery of Pyrrole−Indoline-2-ones as Aurora Kinase Inhibitors with a Different Inhibition Profile Article Snippet: A series of pyrrole-indolin-2-ones were synthesized, and their inhibition profile for Aurora kinases was studied.. The potent compound 33with phenylsulfonamido at theC-5 position and a carboxyethyl group at the C-30 position selectively inhibited Aurora A over Aurora B with IC50 values of 12 and 156 nM, respectively.. Replacement of the carboxyl group with an amino group led to compound 47, which retained the activity for Aurora B and lost activity for Aurora A (IC50= 2.19 μM). Article Title: Design, synthesis, and bioevaluation of paeonol derivatives as potential anti-HBV agents Article Snippet: Hepatitis B virus (HBV) is a causative reagent that frequently causes progressive liver diseases, leading to the development of acute, chronic hepatitis, cirrhosis, and eventually hepatocellular carcinoma (HCC).. Despite several antiviral drugs including interferon-a and nucleotide derivatives are approved for clinical treatment for HBV, critical issues remain unresolved, e.g., low-to-moderate efficacy, adverse side effects, and resistant strains.. In this study, novel Paeonol-phenylsulfonyl derivatives were synthesized and their antiviral effect against HBV was evaluated. Purification:Article Title: Hepatocellular carcinoma targeting agents: conjugates of nitroimidazoles with trimethyl nordihydroguaiaretic acid. Article Snippet: Hepatocellular carcinoma (HCC) is a major global health problem, with >626 000 new cases per year worldwide.. In North America, Asia, and Europe, it is the third highest cause of cancer-related death, behind lung and colon cancers.. 3] A rise in the incidence and mortality of HCC has been observed in most industrialized nations over the past three decades. Article Title: Multi-arm linker for treating rejection reaction in transplantation Article Snippet: .. Analytical thin-layer chromatography (TLC) was performed on precoated plates (silica gel 60 F-254), purchased from Merck Inc. Purification by column chromatography was conducted using Merck Article Title: Discovery of 4-Aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 Inhibitors. Part I: Optimization of in Vitro Potencies and Pharmacokinetic Properties Article Snippet: A series of 4-aryl-N-arylcarbonyl-2-aminothiazoles of scaffold 4 was designed and synthesized as Hec1/ Nek2 inhibitors.. Structural optimization of 4 led to compound 32 bearing C-4′ 4-methoxyphenoxy and 4-(o-fluoropyridyl)carbonyl groups that showed low nanomolar in vitro antiproliferative activity (IC50: 16.3−42.7 nM), high intravenous AUC (64.9 μM·h, 2.0 mg/kg) in SD rats, and significant in vivo antitumor activity (T/C = 32%, 20 mg/kg, IV) in mice bearing human MDA-MB-231 xenografts.. Cell responses resulting from Hec1/Nek2 inhibition were observed in cells treated with 32, including a reduced level of Hec1 coimmunoprecipitated with Nek2, degradation of Nek2, mitotic abnormalities, and apoptosis. Article Title: Discovery of Pyrrole−Indoline-2-ones as Aurora Kinase Inhibitors with a Different Inhibition Profile Article Snippet: A series of pyrrole-indolin-2-ones were synthesized, and their inhibition profile for Aurora kinases was studied.. The potent compound 33with phenylsulfonamido at theC-5 position and a carboxyethyl group at the C-30 position selectively inhibited Aurora A over Aurora B with IC50 values of 12 and 156 nM, respectively.. Replacement of the carboxyl group with an amino group led to compound 47, which retained the activity for Aurora B and lost activity for Aurora A (IC50= 2.19 μM). Article Title: Design, synthesis, and bioevaluation of paeonol derivatives as potential anti-HBV agents Article Snippet: Hepatitis B virus (HBV) is a causative reagent that frequently causes progressive liver diseases, leading to the development of acute, chronic hepatitis, cirrhosis, and eventually hepatocellular carcinoma (HCC).. Despite several antiviral drugs including interferon-a and nucleotide derivatives are approved for clinical treatment for HBV, critical issues remain unresolved, e.g., low-to-moderate efficacy, adverse side effects, and resistant strains.. In this study, novel Paeonol-phenylsulfonyl derivatives were synthesized and their antiviral effect against HBV was evaluated. Column Chromatography:Article Title: Hepatocellular carcinoma targeting agents: conjugates of nitroimidazoles with trimethyl nordihydroguaiaretic acid. Article Snippet: Hepatocellular carcinoma (HCC) is a major global health problem, with >626 000 new cases per year worldwide.. In North America, Asia, and Europe, it is the third highest cause of cancer-related death, behind lung and colon cancers.. 3] A rise in the incidence and mortality of HCC has been observed in most industrialized nations over the past three decades. Article Title: Multi-arm linker for treating rejection reaction in transplantation Article Snippet: .. Analytical thin-layer chromatography (TLC) was performed on precoated plates (silica gel 60 F-254), purchased from Merck Inc. Purification by column chromatography was conducted using Merck Article Title: Discovery of 4-Aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 Inhibitors. Part I: Optimization of in Vitro Potencies and Pharmacokinetic Properties Article Snippet: A series of 4-aryl-N-arylcarbonyl-2-aminothiazoles of scaffold 4 was designed and synthesized as Hec1/ Nek2 inhibitors.. Structural optimization of 4 led to compound 32 bearing C-4′ 4-methoxyphenoxy and 4-(o-fluoropyridyl)carbonyl groups that showed low nanomolar in vitro antiproliferative activity (IC50: 16.3−42.7 nM), high intravenous AUC (64.9 μM·h, 2.0 mg/kg) in SD rats, and significant in vivo antitumor activity (T/C = 32%, 20 mg/kg, IV) in mice bearing human MDA-MB-231 xenografts.. Cell responses resulting from Hec1/Nek2 inhibition were observed in cells treated with 32, including a reduced level of Hec1 coimmunoprecipitated with Nek2, degradation of Nek2, mitotic abnormalities, and apoptosis. Article Title: Discovery of Pyrrole−Indoline-2-ones as Aurora Kinase Inhibitors with a Different Inhibition Profile Article Snippet: A series of pyrrole-indolin-2-ones were synthesized, and their inhibition profile for Aurora kinases was studied.. The potent compound 33with phenylsulfonamido at theC-5 position and a carboxyethyl group at the C-30 position selectively inhibited Aurora A over Aurora B with IC50 values of 12 and 156 nM, respectively.. Replacement of the carboxyl group with an amino group led to compound 47, which retained the activity for Aurora B and lost activity for Aurora A (IC50= 2.19 μM). Article Title: Mild and Efficient Copper-Catalyzed Synthesis of Trisubstituted Pyrroles Article Snippet: A sustainable and time economic approach has been developed for the synthesis of polysubstituted pyrroles using copper iodide as a catalyst.. The reaction proceeded through imine formation followed by cyclization with alkyne-Cu intermediate, which was supported by control experiments studies.. The newly formed substituted pyrroles were obtained in excellent yields with high regioselectivity under mild conditions. Article Title: Design, synthesis, and bioevaluation of paeonol derivatives as potential anti-HBV agents Article Snippet: Hepatitis B virus (HBV) is a causative reagent that frequently causes progressive liver diseases, leading to the development of acute, chronic hepatitis, cirrhosis, and eventually hepatocellular carcinoma (HCC).. Despite several antiviral drugs including interferon-a and nucleotide derivatives are approved for clinical treatment for HBV, critical issues remain unresolved, e.g., low-to-moderate efficacy, adverse side effects, and resistant strains.. In this study, novel Paeonol-phenylsulfonyl derivatives were synthesized and their antiviral effect against HBV was evaluated. |